I posted these tips a while back, but they still apply;
If you are planning a trip to the Southern Appalachians for the fall color season and want to stay in hotel or lodge accommodations, have reservations in advance. Many times I have seen travelers on the Blue Ridge Parkway in October thinking that they would just take a leisurely drive and find a motel room at the end of the day. In many cases they would find no room at the inn. I have seen people drive seventy five miles or more away from the park to find a vacant room.
October is the peak visitation season for this region of the country and a pretty weekend can see huge crowds in the parks.
October is also college football season. Colleges also sponsor their family and alumni weekends durng the beautiful fall weather. Such events can fill hotels for miles. You can check college web sites for their schedules. Some of the key colleges that may affect hotel availability are:
The University of Virginia
Virginia Military Institute
Washington and Lee University
Appalachian State University
University of North Carolina At Asheville
Fall festivals in specific communities can be a great attraction to visit, but also fill hotels.
Traffic in prime viewing areas may also become congested which will result in slow downs and delays. So make your plans for the distances you travel are reasonable and attainable. Come the end of the day you do not want to be hundreds of miles away from your planned stop for the night.
When ever possible travel during the week. Weekends are always the peak traffic times. Hotels rooms are also more easily obtainable on weekday nights.